mTOR in Down Syndrome: Role in Aβ and Tau Neuropathology and Transition to Alzheimer Disease-Like Dementia

The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase involved in the regulation of protein synthesis and degradation, longevity and cytoskeletal formation. The mTOR pathway represents a key growth and survival pathway involved in several diseases such as cancer, obesity, car...

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Vydáno v:Free Radic Biol Med
Hlavní autoři: Di Domenico, Fabio, Tramutola, Antonella, Foppoli, Cesira, Head, Elisabeth, Perluigi, Marzia, Butterfield, D. Allan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748251/
https://ncbi.nlm.nih.gov/pubmed/28807816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.08.009
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