The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

Down syndrome (DS) is the most common genetic cause of intellectual disability that is associated with an increased risk to develop early-onset Alzheimer-like dementia (AD). The brain neuropathological features include alteration of redox homeostasis, mitochondrial deficits, inflammation, accumulati...

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Bibliographic Details
Published in:Antioxidants (Basel)
Main Authors: Perluigi, Marzia, Tramutola, Antonella, Pagnotta, Sara, Barone, Eugenio, Butterfield, D. Allan
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554729/
https://ncbi.nlm.nih.gov/pubmed/32839417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9090779
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