Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

Down syndrome (DS) is the most frequent genetic cause of intellectual disability characterized by the presence of three copies of chromosome 21 (Chr21). Individuals with DS have sufficient neuropathology for a diagnosis of Alzheimer's disease (AD) after the age of 40 years. The aim of our study...

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Bibliografische gegevens
Hoofdauteurs: Perluigi, Marzia, Pupo, Gilda, Tramutola, Antonella, Cini, Chiara, Coccia, Raffaella, Barone, Eugenio, Head, Elizabeth, Butterfield, D. Allan, Di Domenico, Fabio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062876/
https://ncbi.nlm.nih.gov/pubmed/24735980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.04.007
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