Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

BACKGROUND: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the...

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Publicado en:Transl Neurodegener
Autores principales: Tramutola, Antonella, Lanzillotta, Chiara, Barone, Eugenio, Arena, Andrea, Zuliani, Ilaria, Mosca, Luciana, Blarzino, Carla, Butterfield, D. Allan, Perluigi, Marzia, Di Domenico, Fabio
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218962/
https://ncbi.nlm.nih.gov/pubmed/30410750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-018-0133-9
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