ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE

Down Syndrome (DS) is the most common genetic cause of intellectual disability resulting from trisomy of chromosome 21. The main feature of DS neuropathology includes early onset of Alzheimer's disease, with deposition of senile plaques and tangles. We hypothesized that apoptosis may be activat...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Tramutola, Antonella, Pupo, Gilda, Di Domenico, Fabio, Barone, Eugenio, Arena, Andrea, Lanzillotta, Chiara, Brokeaart, Diede, Blarzino, Carla, Head, Elizabeth, Butterfield, D Allan, Perluigi, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968087/
https://ncbi.nlm.nih.gov/pubmed/26967221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-151105
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