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Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-A system: insights for transition to Alzheimer Disease

Bach1, among the genes encoded on chromosome 21, is a transcription repressor, which binds to antioxidant response elements (AREs) of DNA thus inhibiting the transcription of specific genes involved in the cell stress response including heme oxygenase-1 (HO-1). HO-1 and its partner, biliverdin reduc...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Domenico, Fabio Di, Pupo, Gilda, Mancuso, Cesare, Barone, Eugenio, Paolini, Francesca, Arena, Andrea, Blarzino, Carla, Schmitt, Frederick A., Head, Elizabeth, Butterfield, D. Allan, Perluigi, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677575/
https://ncbi.nlm.nih.gov/pubmed/25391381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-141254
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