Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

BACKGROUND: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transl Neurodegener
Hauptverfasser: Tramutola, Antonella, Lanzillotta, Chiara, Barone, Eugenio, Arena, Andrea, Zuliani, Ilaria, Mosca, Luciana, Blarzino, Carla, Butterfield, D. Allan, Perluigi, Marzia, Di Domenico, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218962/
https://ncbi.nlm.nih.gov/pubmed/30410750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-018-0133-9
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge