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A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family

The amino acid sequences of proteins have evolved over billions of years, preserving their structures and functions while responding to evolutionary forces. Are there conserved sequence and structural elements that preserve the protein folding mechanisms? The functionally diverse and ancient (βα)(1–...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Jain, Rohit, Muneeruddin, Khaja, Anderson, Jeremy, Harms, Michael J., Shaffer, Scott A., Matthews, C. Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092565/
https://ncbi.nlm.nih.gov/pubmed/33875592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019571118
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