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Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein

The earliest kinetic folding events for (βα)(8) barrels reflect the appearance of off-pathway intermediates. Continuous-flow microchannel mixing methods interfaced to small-angle x-ray scattering (SAXS), circular dichroism (CD), time-resolved Förster resonant energy transfer (trFRET), and time-resol...

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Detalhes bibliográficos
Main Authors: Wu, Ying, Kondrashkina, Elena, Kayatekin, Can, Matthews, C. Robert, Bilsel, Osman
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533196/
https://ncbi.nlm.nih.gov/pubmed/18757725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802788105
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