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Frustration and folding of a TIM barrel protein

Triosephosphate isomerase (TIM) barrel proteins have not only a conserved architecture that supports a myriad of enzymatic functions, but also a conserved folding mechanism that involves on- and off-pathway intermediates. Although experiments have proven to be invaluable in defining the folding free...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Halloran, Kevin T., Wang, Yanming, Arora, Karunesh, Chakravarthy, Srinivas, Irving, Thomas C., Bilsel, Osman, Brooks, Charles L., Matthews, C. Robert
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697809/
https://ncbi.nlm.nih.gov/pubmed/31346089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900880116
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