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Interplay between Drying and Stability of a TIM Barrel Protein: A Combined Simulation-Experimental Study

Recent molecular dynamics simulations have suggested important roles for nanoscale dewetting on the stability, function, and folding dynamics of proteins. Using a synergistic simulation-experimental approach on the αTS TIM barrel protein, we validate this hypothesis by revealing the occurrence of dr...

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Bibliografische gegevens
Hoofdauteurs: Das, Payel, Kapoor, Divya, Halloran, Kevin T., Zhou, Ruhong, Matthews, C. Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637939/
https://ncbi.nlm.nih.gov/pubmed/23293932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310544t
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