A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family

The amino acid sequences of proteins have evolved over billions of years, preserving their structures and functions while responding to evolutionary forces. Are there conserved sequence and structural elements that preserve the protein folding mechanisms? The functionally diverse and ancient (βα)(1–...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Jain, Rohit, Muneeruddin, Khaja, Anderson, Jeremy, Harms, Michael J., Shaffer, Scott A., Matthews, C. Robert
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092565/
https://ncbi.nlm.nih.gov/pubmed/33875592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019571118
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