A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family

The amino acid sequences of proteins have evolved over billions of years, preserving their structures and functions while responding to evolutionary forces. Are there conserved sequence and structural elements that preserve the protein folding mechanisms? The functionally diverse and ancient (βα)(1–...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jain, Rohit, Muneeruddin, Khaja, Anderson, Jeremy, Harms, Michael J., Shaffer, Scott A., Matthews, C. Robert
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092565/
https://ncbi.nlm.nih.gov/pubmed/33875592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019571118
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