First-in-Human Assessment of (11)C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer

This was a first-in-human study of the PET radiotracer (11)C-LSN3172176 for the muscarinic acetylcholine receptor subtype M1. The objectives of the study were to determine the appropriate kinetic model to quantify binding of the tracer to M1 receptors, and the reliability of the chosen quantificatio...

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Bibliographic Details
Published in:J Nucl Med
Main Authors: Naganawa, Mika, Nabulsi, Nabeel, Henry, Shannan, Matuskey, David, Lin, Shu-Fei, Slieker, Lawrence, Schwarz, Adam J., Kant, Nancy, Jesudason, Cynthia, Ruley, Kevin, Navarro, Antonio, Gao, Hong, Ropchan, Jim, Labaree, David, Carson, Richard E., Huang, Yiyun
Format: Artigo
Language:Inglês
Published: Society of Nuclear Medicine 2021
Subjects:
Neurology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049371/
https://ncbi.nlm.nih.gov/pubmed/32859711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.120.246967
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