Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to evade almost all mechanisms of clinically relevant aminoglycoside resistance. Model‐informed drug development may facilitate its transition from preclinical to clinical phase. This study explored the potential of ph...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Sou, Tomás, Hansen, Jon, Liepinsh, Edgars, Backlund, Maria, Ercan, Onur, Grinberga, Solveiga, Cao, Sha, Giachou, Paraskevi, Petersson, Anna, Tomczak, Magdalena, Urbas, Malgorzata, Zabicka, Dorota, Vingsbo Lundberg, Carina, Hughes, Diarmaid, Hobbie, Sven N., Friberg, Lena E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048880/
https://ncbi.nlm.nih.gov/pubmed/33150591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2104
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