Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to evade almost all mechanisms of clinically relevant aminoglycoside resistance. Model‐informed drug development may facilitate its transition from preclinical to clinical phase. This study explored the potential of ph...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Pharmacol Ther
Egile Nagusiak: Sou, Tomás, Hansen, Jon, Liepinsh, Edgars, Backlund, Maria, Ercan, Onur, Grinberga, Solveiga, Cao, Sha, Giachou, Paraskevi, Petersson, Anna, Tomczak, Magdalena, Urbas, Malgorzata, Zabicka, Dorota, Vingsbo Lundberg, Carina, Hughes, Diarmaid, Hobbie, Sven N., Friberg, Lena E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048880/
https://ncbi.nlm.nih.gov/pubmed/33150591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2104
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