Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to evade almost all mechanisms of clinically relevant aminoglycoside resistance. Model‐informed drug development may facilitate its transition from preclinical to clinical phase. This study explored the potential of ph...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Clin Pharmacol Ther
Autori principali: Sou, Tomás, Hansen, Jon, Liepinsh, Edgars, Backlund, Maria, Ercan, Onur, Grinberga, Solveiga, Cao, Sha, Giachou, Paraskevi, Petersson, Anna, Tomczak, Magdalena, Urbas, Malgorzata, Zabicka, Dorota, Vingsbo Lundberg, Carina, Hughes, Diarmaid, Hobbie, Sven N., Friberg, Lena E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048880/
https://ncbi.nlm.nih.gov/pubmed/33150591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2104
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi