Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to evade almost all mechanisms of clinically relevant aminoglycoside resistance. Model‐informed drug development may facilitate its transition from preclinical to clinical phase. This study explored the potential of ph...

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Foilsithe in:Clin Pharmacol Ther
Main Authors: Sou, Tomás, Hansen, Jon, Liepinsh, Edgars, Backlund, Maria, Ercan, Onur, Grinberga, Solveiga, Cao, Sha, Giachou, Paraskevi, Petersson, Anna, Tomczak, Magdalena, Urbas, Malgorzata, Zabicka, Dorota, Vingsbo Lundberg, Carina, Hughes, Diarmaid, Hobbie, Sven N., Friberg, Lena E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048880/
https://ncbi.nlm.nih.gov/pubmed/33150591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2104
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