The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol (PI) 3,4,5-triphosphate phosphatase. Moreover, A...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Huang, Grace, Boesze-Battaglia, Kathleen, Walker, Lisa P., Zekavat, Ali, Schaefer, Zachary P., Blanke, Steven R., Shenker, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039388/
https://ncbi.nlm.nih.gov/pubmed/33854985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.664221
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