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Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate
The Aggregatibactor actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase activity and depletes lymphoid cells of PI...
Wedi'i Gadw mewn:
Cyhoeddwyd yn: | Mol Oral Microbiol |
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Prif Awduron: | , , , |
Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
2015
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712092/ https://ncbi.nlm.nih.gov/pubmed/26299277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/omi.12127 |
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