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Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate

The Aggregatibactor actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase activity and depletes lymphoid cells of PI...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Oral Microbiol
Prif Awduron: Shenker, Bruce J., Walker, Lisa P., Zekavat, Ali, Boesze-Battaglia, Kathleen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712092/
https://ncbi.nlm.nih.gov/pubmed/26299277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/omi.12127
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