Internalization and Intoxication of Human Macrophages by the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent Upon Cellugyrin (Synaptogyrin-2)

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB(2) toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. Recently, we have demonstrated that human macrophages are resistant to Cdt-induced apoptosis but are su...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Boesze-Battaglia, Kathleen, Dhingra, Anuradha, Walker, Lisa M., Zekavat, Ali, Shenker, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325893/
https://ncbi.nlm.nih.gov/pubmed/32655562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01262
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