Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activates the NLRP3 Inflammasome in Human Macrophages, Leading to the Release of Proinflammatory Cytokines

The cytolethal distending toxin (Cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that the active toxin subunit functions as a phosphatidylinositol-3,4,5-triphosph...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Shenker, Bruce J., Ojcius, David M., Walker, Lisa P., Zekavat, Ali, Scuron, Monika Damek, Boesze-Battaglia, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363449/
https://ncbi.nlm.nih.gov/pubmed/25644004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.03132-14
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