The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol (PI) 3,4,5-triphosphate phosphatase. Moreover, A...

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Détails bibliographiques
Publié dans:Front Cell Infect Microbiol
Auteurs principaux: Huang, Grace, Boesze-Battaglia, Kathleen, Walker, Lisa P., Zekavat, Ali, Schaefer, Zachary P., Blanke, Steven R., Shenker, Bruce J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Cellular and Infection Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039388/
https://ncbi.nlm.nih.gov/pubmed/33854985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.664221
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