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The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol (PI) 3,4,5-triphosphate phosphatase. Moreover, A...

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Bibliografiset tiedot
Julkaisussa:Front Cell Infect Microbiol
Päätekijät: Huang, Grace, Boesze-Battaglia, Kathleen, Walker, Lisa P., Zekavat, Ali, Schaefer, Zachary P., Blanke, Steven R., Shenker, Bruce J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039388/
https://ncbi.nlm.nih.gov/pubmed/33854985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.664221
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