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The Cell-Cycle Regulatory Protein p21(CIP1/WAF1) Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21(CIP1/WAF1) is critical to Cdt-induced apoptosis. Cdt induces increases in t...
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| 發表在: | Pathogens |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7168616/ https://ncbi.nlm.nih.gov/pubmed/31906446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens9010038 |
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