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The Cell-Cycle Regulatory Protein p21(CIP1/WAF1) Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21(CIP1/WAF1) is critical to Cdt-induced apoptosis. Cdt induces increases in t...

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發表在:Pathogens
Main Authors: Shenker, Bruce J., Walker, Lisa M., Zekavat, Ali, Weiss, Robert H., Boesze-Battaglia, Kathleen
格式: Artigo
語言:Inglês
出版: MDPI 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7168616/
https://ncbi.nlm.nih.gov/pubmed/31906446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens9010038
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