A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6

Protein arginine methyltransferase 6 (PRMT6) catalyzes monomethylation and asymmetric dimethylation of arginine residues in various proteins, plays important roles in biological processes, and is associated with multiple cancers. To date, a highly selective PRMT6 inhibitor has not been reported. Her...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Shen, Yudao, Li, Fengling, Szewczyk, Magdalena M., Halabelian, Levon, Chau, Irene, Eram, Mohammad S., Seña, Carlo Dela, Park, Kwang-Su, Meng, Fanye, Chen, He, Zeng, Hong, McLeod, David, Zepeda-Velázquez, Carlos A., Campbell, Robert M., Mader, Mary M., Watson, Brian M., Schapira, Matthieu, Arrowsmith, Cheryl H., Al-Awar, Rima, Barsyte-Lovejoy, Dalia, Kaniskan, H. Ümit, Brown, Peter J., Vedadi, Masoud, Jin, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035306/
https://ncbi.nlm.nih.gov/pubmed/33591753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02160
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