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Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal cells. Depletion of mHtt enhances protein synth...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7935949/ https://ncbi.nlm.nih.gov/pubmed/33674575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21637-y |
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