Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal cells. Depletion of mHtt enhances protein synth...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Eshraghi, Mehdi, Karunadharma, Pabalu P., Blin, Juliana, Shahani, Neelam, Ricci, Emiliano P., Michel, Audrey, Urban, Nicolai T., Galli, Nicole, Sharma, Manish, Ramírez-Jarquín, Uri Nimrod, Florescu, Katie, Hernandez, Jennifer, Subramaniam, Srinivasa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935949/
https://ncbi.nlm.nih.gov/pubmed/33674575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21637-y
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