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Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal cells. Depletion of mHtt enhances protein synth...

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Vydáno v:Nat Commun
Hlavní autoři: Eshraghi, Mehdi, Karunadharma, Pabalu P., Blin, Juliana, Shahani, Neelam, Ricci, Emiliano P., Michel, Audrey, Urban, Nicolai T., Galli, Nicole, Sharma, Manish, Ramírez-Jarquín, Uri Nimrod, Florescu, Katie, Hernandez, Jennifer, Subramaniam, Srinivasa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935949/
https://ncbi.nlm.nih.gov/pubmed/33674575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21637-y
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