Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal cells. Depletion of mHtt enhances protein synth...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Eshraghi, Mehdi, Karunadharma, Pabalu P., Blin, Juliana, Shahani, Neelam, Ricci, Emiliano P., Michel, Audrey, Urban, Nicolai T., Galli, Nicole, Sharma, Manish, Ramírez-Jarquín, Uri Nimrod, Florescu, Katie, Hernandez, Jennifer, Subramaniam, Srinivasa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935949/
https://ncbi.nlm.nih.gov/pubmed/33674575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21637-y
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