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Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Sharma, Manish, Rajendrarao, Sumitha, Shahani, Neelam, Ramírez-Jarquín, Uri Nimrod, Subramaniam, Srinivasa
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354937/
https://ncbi.nlm.nih.gov/pubmed/32581130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002144117
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