Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sharma, Manish, Rajendrarao, Sumitha, Shahani, Neelam, Ramírez-Jarquín, Uri Nimrod, Subramaniam, Srinivasa
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354937/
https://ncbi.nlm.nih.gov/pubmed/32581130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002144117
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