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Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7354937/ https://ncbi.nlm.nih.gov/pubmed/32581130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002144117 |
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