Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation. In this study, we examined whether cGAS plays a rol...

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Detalles Bibliográficos
Publicado en:Mediators Inflamm
Main Authors: Wang, Yan, Su, Guo-Hua, Zhang, Fang, Chu, Jing-Xue, Wang, Yun-Shan
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706940/
https://ncbi.nlm.nih.gov/pubmed/26819496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/192329
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