Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis

Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Smoothened (Smo) is a key component of sonic hedgehog (Shh) signaling and contributes to tumor cell proliferation. The objective of this study was to investigate the role of Smo in RA synoviocyte pro...

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Gepubliceerd in:Cell Mol Immunol
Hoofdauteurs: Zhu, Shang-ling, Huang, Jian-lin, Peng, Wei-xiang, Wu, Dan-chun, Luo, Min-qi, Li, Qiu-xia, Li, Zhao-xia, Feng, Xiao-xue, Liu, Fang, Wang, Ming-xia, Chen, Wei-qian, Olsen, Nancy, Zheng, Song Guo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301154/
https://ncbi.nlm.nih.gov/pubmed/26189371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.67
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