Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling

Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy. The objective of this study is to explore the role of c-Jun N-terminal kinase (JNK) in p...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhu, Shangling, Ye, Yuanmei, Shi, Yiming, Dang, Junlong, Feng, Xiaoxue, Chen, Yingdi, Liu, Fang, Olsen, Nancy, Huang, Jianlin, Zheng, Song Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326768/
https://ncbi.nlm.nih.gov/pubmed/32670287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01300
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