Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Fibroblast-like synoviocytes (FLSs) are the major effector cells that lead to rheumatoid arthritis (RA) synovitis and joint destruction. Our previous studies showed that Sonic Hedgehog (SHH) signaling pathway is involved in aberrant activation of RA-FLSs and inhibition of SHH pathway decreases proli...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liu, Fang, Feng, Xiao Xue, Zhu, Shang Ling, Huang, Hong Yu, Chen, Ying Di, Pan, Yun Feng, June, Rayford R., Zheng, Song Guo, Huang, Jian Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290332/
https://ncbi.nlm.nih.gov/pubmed/30568656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02847
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