Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Fibroblast-like synoviocytes (FLSs) are the major effector cells that lead to rheumatoid arthritis (RA) synovitis and joint destruction. Our previous studies showed that Sonic Hedgehog (SHH) signaling pathway is involved in aberrant activation of RA-FLSs and inhibition of SHH pathway decreases proli...

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Foilsithe in:Front Immunol
Main Authors: Liu, Fang, Feng, Xiao Xue, Zhu, Shang Ling, Huang, Hong Yu, Chen, Ying Di, Pan, Yun Feng, June, Rayford R., Zheng, Song Guo, Huang, Jian Lin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290332/
https://ncbi.nlm.nih.gov/pubmed/30568656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02847
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