Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

Fibroblast-like synoviocytes (FLSs) acquire aggressive phenotypes characterized with enhanced migration abilities and inherent invasive qualities in rheumatoid arthritis (RA). Smoothened (Smo) is a key component of sonic hedgehog (Shh) signaling and contributes to tumor cell invasion and metastasis....

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Bibliographic Details
Published in:Front Immunol
Main Authors: Peng, Wei-xiang, Zhu, Shang-ling, Zhang, Bai-yu, Shi, Yi-ming, Feng, Xiao-xue, Liu, Fang, Huang, Jian-lin, Zheng, Song Guo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309251/
https://ncbi.nlm.nih.gov/pubmed/28261216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00159
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