ACTIVATION OF ERK BY SONIC HEDGEHOG INDEPENDENT OF CANONICAL HEDGEHOG SIGNALLING

Hedgehog (Hh) signalling is mediated through the Patched-1 (Ptch1) receptor. Hh-binding to Ptch1 blocks the inhibitory effects of Ptch1 on the activity of the transmembrane protein, Smoothened (Smo), resulting induction of target genes by the Gli-family of transcription factors. We demonstrate here...

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Main Authors: Chang, Hong, Li, Qing, Moraes, Ricardo C., Lewis, Michael T., Hamel, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038129/
https://ncbi.nlm.nih.gov/pubmed/20451654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.04.016
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