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ACTIVATION OF ERK BY SONIC HEDGEHOG INDEPENDENT OF CANONICAL HEDGEHOG SIGNALLING
Hedgehog (Hh) signalling is mediated through the Patched-1 (Ptch1) receptor. Hh-binding to Ptch1 blocks the inhibitory effects of Ptch1 on the activity of the transmembrane protein, Smoothened (Smo), resulting induction of target genes by the Gli-family of transcription factors. We demonstrate here...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038129/ https://ncbi.nlm.nih.gov/pubmed/20451654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.04.016 |
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