Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

[Image: see text] Tuberculosis remains a leading cause of death from a single bacterial infection worldwide. Efforts to develop new treatment options call for expansion into an unexplored target space to expand the drug pipeline and bypass resistance to current antibiotics. Lipoamide dehydrogenase i...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:ACS Infect Dis
Huvudupphovsmän: Ginn, John, Jiang, Xiuju, Sun, Shan, Michino, Mayako, Huggins, David J., Mbambo, Zodwa, Jansen, Robert, Rhee, Kyu Y., Arango, Nancy, Lima, Christopher D., Liverton, Nigel, Imaeda, Toshihiro, Okamoto, Rei, Kuroita, Takanobu, Aso, Kazuyoshi, Stamford, Andrew, Foley, Michael, Meinke, Peter T., Nathan, Carl, Bryk, Ruslana
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2021
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888283/
https://ncbi.nlm.nih.gov/pubmed/33527832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00788
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk