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Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase
Mycobacterium tuberculosis (Mtb) remains the leading single cause of death from bacterial infection. Here we explored the possibility of species-selective inhibition of lipoamide dehydrogenase (Lpd), an enzyme central to Mtb’s intermediary metabolism and antioxidant defense. High-throughput screenin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2827632/ https://ncbi.nlm.nih.gov/pubmed/20078138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9016186 |
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