Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase,

Tuberculosis remains a global health emergency that calls for treatment regimens directed at new targets. Here we explored lipoamide dehydrogenase, a metabolic and detoxifying enzyme in Mycobacterium tuberculosis whose deletion drastically impairs Mtb's ability to establish infection in the mou...

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Detalhes bibliográficos
Main Authors: Bryk, Ruslana, Arango, Nancy, Maksymiuk, Christina, Balakrishnan, Anand, Wu, Ying-Ta, Wong, Chi-Huey, Masquelin, Thierry, Hipskind, Philip, Lima, Christopher D., Nathan, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894633/
https://ncbi.nlm.nih.gov/pubmed/24251446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401077f
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