Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multi-enzyme complexes

Mycobacterium tuberculosis (Mtb) adapts to persist in a nutritionally limited macrophage compartment. Lipoamide dehydrogenase (Lpd), the third enzyme (E3) in Mtb’s pyruvate dehydrogenase complex (PDH), also serves as E1 of peroxynitrite reductase/peroxidase (PNR/P), which helps Mtb resist host react...

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Main Authors: Venugopal, Aditya, Bryk, Ruslana, Shi, Shuangping, Rhee, Kyu, Rath, Poonam, Schnappinger, Dirk, Ehrt, Sabine, Nathan, Carl
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040420/
https://ncbi.nlm.nih.gov/pubmed/21238944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.12.004
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