Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

[Image: see text] Tuberculosis remains a leading cause of death from a single bacterial infection worldwide. Efforts to develop new treatment options call for expansion into an unexplored target space to expand the drug pipeline and bypass resistance to current antibiotics. Lipoamide dehydrogenase i...

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Publicado en:ACS Infect Dis
Main Authors: Ginn, John, Jiang, Xiuju, Sun, Shan, Michino, Mayako, Huggins, David J., Mbambo, Zodwa, Jansen, Robert, Rhee, Kyu Y., Arango, Nancy, Lima, Christopher D., Liverton, Nigel, Imaeda, Toshihiro, Okamoto, Rei, Kuroita, Takanobu, Aso, Kazuyoshi, Stamford, Andrew, Foley, Michael, Meinke, Peter T., Nathan, Carl, Bryk, Ruslana
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2021
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888283/
https://ncbi.nlm.nih.gov/pubmed/33527832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00788
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