Macrocyclic peptides that selectively inhibit the Mycobacterium tuberculosis proteasome

Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) are phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill non-replicating (NR) Mtb may shorten treatment when used in combination with conventional drugs. The M...

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Publicado no:J Med Chem
Main Authors: Zhang, Hao, Hsu, Hao-Chi, Kahne, Shoshanna C., Hara, Ryoma, Zhan, Wenhu, Jiang, Xiuju, Burns-Huang, Kristin, Ouellette, Tierra, Imaeda, Toshihiro, Okamoto, Rei, Kawasaki, Masanori, Michino, Mayako, Wong, Tzu-Tshin, Toita, Akinori, Yukawa, Takafumi, Moraca, Francesca, Vendome, Jeremie, Saha, Priya, Sato, Kenjiro, Aso, Kazuyoshi, Ginn, John, Meinke, Peter T., Foley, Michael, Nathan, Carl F, Darwin, K. Heran, Li, Huilin, Lin, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8194371/
https://ncbi.nlm.nih.gov/pubmed/33949190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00296
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