Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice

Plasmodium falciparum proteasome (Pf20S) inhibitors are active against Plasmodium at multiple stages – erythrocytic stages, gametocyte stages, liver stages and gamete activation, indicating that selective Pf20S inhibitors possess the potential to be therapeutic, prophylactic and transmission-blockin...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu-Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente-Monasterio, Maria Jose, Martinez-Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087158/
https://ncbi.nlm.nih.gov/pubmed/33433953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015845
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