Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome

Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Co-evolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-imposed nitrosative and oxidative stresses. Genetic deletion or pharmacological inhibition of the Mtb prote...

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發表在:J Med Chem
Main Authors: Zhan, Wenhu, Hsu, Hao-Chi, Morgan, Trevor, Ouellette, Tierra, Burns-Huang, Kristin, Hara, Ryoma, Wright, Adrian G., Imaeda, Toshihiro, Okamoto, Rei, Sato, Kenjiro, Michino, Mayako, Ramjee, Manoj, Aso, Kazuyoshi, Meinke, Peter T., Foley, Michael, Nathan, Carl F, Li, Huilin, Lin, Gang
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091493/
https://ncbi.nlm.nih.gov/pubmed/31560200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01187
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