Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors

The Plasmodium proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite life cycle and synergize with artemisinins, suggesting that Pf20S inhibitors have potential to be prophylactic, therapeutic, transmission blocking as well as useful...

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Опубликовано в: :J Med Chem
Главные авторы: Zhan, Wenhu, Visone, Joseph, Ouellette, Tierra, Harris, Jacob C., Wang, Rong, Zhang, Hao, Singh, Pradeep K, Ginn, John, Sukenick, George, Wong, Tzu-Tshin, Okoro, Judith I., Scales, Ryan M., Tumwebaze, Patrick K., Rosenthal, Philip J., Kafsack, Björn F.C., Cooper, Roland A., Meinke, Peter T., Kirkman, Laura A., Lin, Gang
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104388/
https://ncbi.nlm.nih.gov/pubmed/31177777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00363
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