Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors

The Plasmodium proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite life cycle and synergize with artemisinins, suggesting that Pf20S inhibitors have potential to be prophylactic, therapeutic, transmission blocking as well as useful...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Zhan, Wenhu, Visone, Joseph, Ouellette, Tierra, Harris, Jacob C., Wang, Rong, Zhang, Hao, Singh, Pradeep K, Ginn, John, Sukenick, George, Wong, Tzu-Tshin, Okoro, Judith I., Scales, Ryan M., Tumwebaze, Patrick K., Rosenthal, Philip J., Kafsack, Björn F.C., Cooper, Roland A., Meinke, Peter T., Kirkman, Laura A., Lin, Gang
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104388/
https://ncbi.nlm.nih.gov/pubmed/31177777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00363
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires