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Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation

Mycobacterium tuberculosis uses a proteasome system that is analogous to the eukaryotic ubiquitin-proteasome pathway and is required for pathogenesis. However, the bacterial analogue of ubiquitin, prokaryotic ubiquitin-like protein (Pup), is an intrinsically disordered protein bearing little sequenc...

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Bibliografische gegevens
Hoofdauteurs: Wang, Tao, Darwin, K. Heran, Li, Huilin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988878/
https://ncbi.nlm.nih.gov/pubmed/20953180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1918
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