Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates

The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pup is unstable and never observed in extracts of M. tubercul...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Zhang, Susan, Burns-Huang, Kristin E., Janssen, Guido V., Li, Huilin, Ovaa, Huib, Hedstrom, Lizbeth, Darwin, K. Heran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358908/
https://ncbi.nlm.nih.gov/pubmed/28223451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00122-17
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