Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

Tyrosyl-DNA phosphodiesterase 2 repairs irreversible topoisomerase II-mediated cleavage complexes generated by anticancer topoisomerase-targeted drugs and processes replication intermediates for picornaviruses (VPg unlinkase) and hepatitis B virus. There is currently no TDP2 inhibitor in clinical de...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Marchand, Christophe, Abdelmalak, Monica, Kankanala, Jayakanth, Huang, Shar-Yin, Kiselev, Evgeny, Fesen, Katherine, Kurahashi, Kayo, Sasanuma, Hiroyuki, Takeda, Shunichi, Aihara, Hideki, Wang, Zhengqiang, Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857643/
https://ncbi.nlm.nih.gov/pubmed/27128689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01047
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