Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

Tyrosyl-DNA phosphodiesterase 2 repairs irreversible topoisomerase II-mediated cleavage complexes generated by anticancer topoisomerase-targeted drugs and processes replication intermediates for picornaviruses (VPg unlinkase) and hepatitis B virus. There is currently no TDP2 inhibitor in clinical de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Biol
Prif Awduron: Marchand, Christophe, Abdelmalak, Monica, Kankanala, Jayakanth, Huang, Shar-Yin, Kiselev, Evgeny, Fesen, Katherine, Kurahashi, Kayo, Sasanuma, Hiroyuki, Takeda, Shunichi, Aihara, Hideki, Wang, Zhengqiang, Pommier, Yves
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857643/
https://ncbi.nlm.nih.gov/pubmed/27128689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01047
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg