A Self-Assembling and DisAssembling (SADA) bispecific antibody (BsAb) platform for curative 2-step pre-targeted radioimmunotherapy

PURPOSE: Many cancer treatments suffer from dose-limiting toxicities to vital organs due to poor therapeutic indices (TI). To overcome these challenges we developed a novel multimerization platform that rapidly removed tumor targeting proteins from the blood to substantially improve TI. EXPERIMENTAL...

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Pubblicato in:Clin Cancer Res
Autori principali: Santich, Brian H, Cheal, Sarah M, Ahmed, Mahiuddin, McDevitt, Michael R, Ouerfelli, Ouathek, Yang, Guangbin, Veach, Darren R, Fung, Edward K, Patel, Mitesh, Vargas, Daniela Burnes, Malik, Aiza A, Guo, Hong-Fen, Zanzonico, Pat B, Monette, Sebastien, Michel, Adam O, Rudin, Charles M, Larson, Steven M, Cheung, Nai-Kong V
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855367/
https://ncbi.nlm.nih.gov/pubmed/32958698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2150
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