Evaluation of glycodendron and synthetically-modified dextran clearing agents for multi-step targeting of radioisotopes for molecular imaging and radioimmunotherapy

A series of N-acetylgalactosamine-dendrons (NAG-dendrons) and dextrans bearing biotin moieties were compared for their ability to complex with and sequester circulating bispecific anti-tumor antibody (scFv(4)) streptavidin (SA) fusion protein (scFv(4)-SA) in vivo, to improve tumor to normal tissue c...

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Publicado en:Mol Pharm
Autores principales: Cheal, Sarah M., Yoo, Barney, Boughdad, Sarah, Punzalan, Blesida, Yang, Guangbin, Dilhas, Anna, Torchon, Geralda, Pu, Jun, Axworthy, Don B., Zanzonico, Pat, Ouerfelli, Ouathek, Larson, Steven M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270281/
https://ncbi.nlm.nih.gov/pubmed/24219178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp4003128
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