Pairwise Comparison of (89)Zr- and (124)I-labeled cG250 Based on Positron Emission Tomography Imaging and Non-Linear Immunokinetic Modeling: In Vivo Carbonic Anhydrase IX Receptor Binding and Internalization in Mouse Xenografts of Clear Cell Renal Carcinoma

PURPOSE: The positron-emitting tomography (PET) tracer, (124)I-cG250, directed against carbonic anhydrase IX (CAIX) shows promise for pre-surgical diagnosis of clear renal cell carcinoma (cRCC) [1, 2]. The radiometal zirconium-89 ((89)Zr), however, may offer advantages as a surrogate PET nuclide ove...

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Detalhes bibliográficos
Main Authors: Cheal, Sarah M., Punzalan, Blesida, Doran, Michael G., Evans, Michael J., Osborne, Joseph R., Lewis, Jason S., Zanzonico, Pat, Larson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120276/
https://ncbi.nlm.nih.gov/pubmed/24604591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-013-2679-1
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